Mycinamicins, new macrolide antibiotics. XII. Isolation and structural elucidation of mycinamicins X and XI.
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چکیده
منابع مشابه
Mycinamicins, new macrolide antibiotics. XII. Isolation and structural elucidation of mycinamicins X and XI.
covered four newminor componentsdesignated mycinamicins X (1), X' (2), XI (3) and XI' (4). From physico-chemical properties, spectroscopic data and chemical degradation studies, these compounds were shown to be analogs ofmycinamicins I (5) and II (6), whose structures are different from compounds 5and 6at the C-ll position. In this paper, wedescribe the isolation and structural elucidation of t...
متن کاملMycinamicins, new macrolide antibiotics. XI. Isolation and structure elucidation of a key intermediate in the biosynthesis of the mycinamicins, mycinamicin VIII.
rubida sp. nov., which have strong antibacterial activity against Gram-positive bacteria1\ The complex consists of seven components; mycinamicins I (1), II (2), III (3), IV (4), V (5), VI (6) and VII (7)2~4). During the search for new antibiotics from the fermentation broth of mycinamicinproducing strains, we have discovered a new minor component designated mycinamicin VIII (8). Recently, the s...
متن کاملMycinamicins, new macrolide antibiotics. VIII. Chemical degradation and absolute configuration of mycinamicins.
Mycinamicins, a new family of basic 16membered macrolide antibiotics were produced by Micromonospora griseorubida sp. nov. They consist of at least seven components, named as mycinamicin I (1), 11 (2), III (3), IV (4), V (5), VI (6) and VII (7), and possess strong antibacterial activity against Gram-positive bacteria1-4). In an earlier study, the structures and stereochemistry of mycinamicins w...
متن کاملThe biosynthesis of AR-5 (mycinamicins) antibiotics.
Sir: AR-5 (Mycinamicins) antibiotics, 16-membered ring macrolides, are produced by Micromonospora sp. These novel macrolides are potent antibiotics with unusual activity. Structures of these compounds were independently assigned by us and a group of Japanese workers.',') The assignments of the signals in the 13C NMR spectra have been previously reported". In analogy with the origin of the carbo...
متن کاملISOLATION AND STRUCTURAL ELUCIDATION OF THE FIRST KNOWN C-HOMOPROTOBERBERINE
A novel C-homoprotoberberine alkaloid, Hediamine (2), has been isolated from the roots of Berberis actinucantha (Berberidaceae). Conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (UV, IR, MS, NMR).
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1991
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.44.1270